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A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported in association with promethazine HClpromethazine hydrochloridealone or in combination with antipsychotic drugsClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental status and evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmiasThe diagnostic evaluation of patients with this syndrome is complicatedIn arriving at a diagnosisit is important to identify cases order sarafem side where the clinical presentation includes both serious medical illnesse.gpneumoniasystemic infectionetcand untreated or inadequately treated extrapyramidal signs and symptomsEPSOther important considerations in the differential diagnosis include central anticholinergic toxicityheat strokedrug fever and primary central nervous systemCNSpathology.

Promethazine hydrochloride tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

This is not a complete list of possible side effectsIf you notice other effects not listed abovecontact your doctor or pharmacist.

SECONDARY TO PROMETHAZINE HYDROCHLORIDE TABLETS ADMINISTRATION MAY BE CONFUSED WITH THE CNS SIGNS OF UNDIAGNOSED PRIMARY DISEASEe.gENCEPHALOPATHY OR REYE’S SYNDROMETHE USE OF PROMETHAZINE HCLpromethazine hydrochlorideTABLETS SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE’S SYNDROME OR OTHER HEPATIC DISEASES.

Promethazine may cause other side effectsCall your doctor if you experience any unusual problems while you are taking this medication.

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